Divergent Asymmetric Total Synthesis of the cis-Clerodane Diterpenoids.

Key Points

• The study aims to develop a divergent synthetic strategy for the synthesis of cis-clerodane diterpenoids.
• Utilized reductive ring-opening of isoxazoline for synthesis.
• Applied Stille coupling and ketalization to construct the carbon skeleton.
• Enabled epimerization at C6 during the process.
• A streamlined synthetic strategy was established for clerodane diterpenoids.
• The method allows for the synthesis of other members of the clerodane family.
• Unexpected epimerization at C6 was observed during synthesis.