Key points are not available for this paper at this time.
Funding This study was sponsored by the University of Galway with a research grant from Sino Medical Sciences Technology Inc. Acknowledgement The PIONEER IV trial was sponsored by the University of Galway. We thank the members of the DSMB (Prof. Pedro Lemos, Prof. Dominick Angiolillo, and Dr. Alberto Alvarez-Iglesias) and the Clinical Events Committee (Prof. Scot Garg, Dr. Maik Grundeken, and Dr. Javaid Iqbal) for their contributions to ensuring the safe conduct of the trial and adjudication of events. We are grateful to Medis Medical Imaging for technical support to the sites and the central core laboratory. We also deeply appreciate the intellectual contributions of our visiting scholars, Dr. Gonçalo Costa and Dr. Jacopo Farina, and the guidance of our steering committee members, Prof. William Wijns and Prof. Andrew Smith. Finally, we thank the PIONEER IV coordination, data management, and trial safety teams for their dedication, and we are indebted to the participating patients and investigators.
Serruys et al. (Mon,) studied this question.