Large language models for automated and audience-tailored labeling of latent classes.

Objective: This study compares multiple LLMs, including ChatGPT, DeepSeek, and Llama, to generate meaningful, audience-adapted labels for the existing latent classes among patients with chronic low back pain (cLBP). Methods: = 450). The analysis included pain characteristics, psychosocial factors, lifestyle habits, and social determinants of health. ChatGPT-4o (OpenAI), DeepSeek-R1, and Llama 3.3 (Meta) were applied to generate class labels for each combination of audience (clinician, patient, and caregiver), tone (formal, empathetic, and informal), and technicality (high, medium, and low). Results: , indicating strong conceptual alignment and the capacity of LLMs to generate precise, audience-specific labels for intricate behavioral and psychological profiles. Conclusions: These results highlight the possibility of integrating LLM-driven labeling into research and clinical practice, helping to achieve more transparent knowledge translation, improved decision-making, and personalized care.