Size-Tunable Hemoglobin Oxygen Carriers with Antioxidant and Pro-Angiogenic Functions for Wound Healing

Key Points

• The aim is to develop hemoglobin-based oxygen carriers that improve wound healing through antioxidant and angiogenic functions.
• Synthesis of size-tunable Hb-Oxy via a template-assisted strategy
• Functionalization of Hb-Oxy with caffeic acid (CA)
• Evaluation of oxygen affinity using P50 measurements.
• Optimized Hb-CA building blocks achieved a P50 of 35.84 mmHg and >99% encapsulation efficiency.
• Demonstrated antioxidant and pro-angiogenic properties in vitro and in vivo models.
• Size-tunable properties led to improved wound healing outcomes compared to unmodified carriers.