Background: Hyaluronic acid (HA) and Botulinum toxin A (BTX-A) treatments are highly regarded for their effectiveness in facial rejuvenation. Aim: To investigate whether adding Profhilo enhances the effects of BTX-A for frontal skin rejuvenation. Method: In a prospective clinical trial, 10 subjects were treated by upper face Profhilo plus Botulinum toxin A injection, and 10 age- and sex-matched controls received only Botulinum toxin A injection. Clinical and sonographic improvement were compared 3 months after the last treatment session. Results: values: 0.261 and 0.670, respectively). Conclusion: We have shown that adding Profhilo to BTX-A injection does not have any short-term clinical or sonographic advantage in frontal area wrinkle reduction. Further prospective studies with a longer follow-up period are warranted to evaluate any potential long-term effects.
Saffarian et al. (Tue,) studied this question.