Lower preoperative serum albumin level is an independent predictor of serious postoperative complications following pancreaticoduodenectomy, with an optimal cut-off value of 37.8 g/L.
Cohort (n=92)
No
Does preoperative low albumin level predict serious postoperative complications in patients undergoing pancreaticoduodenectomy for periampullary tumors?
Preoperative serum albumin level ≤37.8 g/L is an independent predictor of serious postoperative complications following pancreaticoduodenectomy for periampullary tumors.
Effect estimate: OR 0.867 (95% CI 0.761-0.989)
p-value: p=0.034
The preoperative identification of patients who are at high risk for serious postoperative outcomes after pancreaticoduodenectomy is important for their management. Our aim was to investigate the factors affecting the serious complications after pancreaticoduodenectomy (PD). 92 patients who were operated for periampullar region tumor were retrospectively analyzed between November 2017 and July 2024. Patients were divided into two groups (patients without serious complication (woSC) and patients with serious complication (wSC)) and these groups were compared with demographic data, laboratory results, pathological findings, perioperative findings, and 30-day mortality rate. Risk factors affecting postoperative serious complications were determined. Logistic regression analyses were performed to identify the risk factors of postoperative serious complication. Twenty-four (26%) patients developed serious complications after PD. The albumin levels were significantly lower in the wSC group compared with the woSC group (p=0.035). The albumin was found to be an independent factor in multivariate analysis. Receiver operating characteristic (ROC) curve analysis showed that 37.8 g/L was the optimal cut-off value for postoperative serious complication in PD. So, lower albumin level (≤37.8 g/L) is associated with increased postoperative serious complications in PD for periampullar cancer.
Zengin et al. (Mon,) conducted a cohort in Periampullary tumor (n=92). Preoperative serum albumin was evaluated on Serious postoperative complications (Clavien-Dindo grade ≥ III) (OR 0.867, 95% CI 0.761-0.989, p=0.034). Lower preoperative serum albumin level is an independent predictor of serious postoperative complications following pancreaticoduodenectomy, with an optimal cut-off value of 37.8 g/L.