The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten.

Key Points

• This research aims to explore the role of lnc13 in modulating inflammatory responses related to gluten tolerance.
• Identified the IL-15-dependent pathway and its implications in celiac disease.
• Analyzed the effects of lnc13 on inflammatory mediator expression.
• Lnc13 significantly reduces inflammatory responses associated with gluten intake.
• Establishes lnc13 as a crucial noncoding modulator of oral gluten tolerance.