This research aims to develop a copper-catalyzed method for protoboration that achieves high enantioselectivity.
Copper-catalyzed protoboration of α-substituted tert-butyl acrylates.
Methodology was scaled up to one gram.
Applied to various stereoselective derivatizations.
High enantioselectivity achieved with different α-substituted tert-butyl acrylates.
Successful scaling of methodology to one gram.
Diverse stereoselective derivatizations performed effectively.
Abstract
-butyl ester group is essential for achieving high enantioselectivity. This methodology has been successfully scaled up to the one-gram level and applied to diverse stereoselective derivatizations.