OBJECTIVE: To evaluate the diagnostic efficacy of virtual magnetic resonance elastography (vMRE) derived from intravoxel incoherent motion (IVIM) imaging in distinguishing prostate cancer (PCa) from benign prostate lesion (BPL). METHODS: and Gleason scores was evaluated using Spearman's rank correlation. Internal validation was performed via 1,000-sample bootstrapping. RESULTS: and PI-RADS v2.1 significantly outperformed PI-RADS v2.1 alone (AUC: 0.941 vs. 0.811, P < 0.001), and it achieved an optimism-corrected AUC of 0.940 in bootstrap validation. CONCLUSION: IVIM-vMRE provides an objective, quantifiable measure of prostate tissue stiffness that correlates with tumor grade. As a non-invasive adjunct to bpMRI, vMRE significantly improves the diagnostic accuracy of PI-RADS v2.1 and facilitates the stratification of tumor aggressiveness.
Wang et al. (Fri,) studied this question.