Structural Modification of Tranilast against Poxvirus Based on α, β-Unsaturated Acrylamide Covalent Warhead and Confirmation of the Targets and Mode of Action.

Key Points

• This research focuses on developing and assessing new derivatives of tranilast for their antiviral properties against poxvirus.
• Designed and synthesized 24 new tranilast derivatives based on α, β-unsaturated acrylamide covalent warheads.
• Evaluated the anti-poxvirus activity of synthesized derivatives in laboratory assays.
• Confirmed the specific targets and mode of action for effective antiviral activity.
• Identified several derivatives with significantly improved antiviral efficacy against poxvirus compared to original tranilast.
• Effectiveness metrics include enhanced binding affinity and selectivity towards viral targets, though specific numerical data is not provided.