Myocardial contrast echocardiography peak intensity (A-value > 8.13 dB) discriminated exercise-induced physiological from hypertension-induced pathological hypertrophy (AUC 0.904).
Observational (n=75)
Does myocardial contrast echocardiography (MCE) accurately differentiate between physiological and pathological myocardial hypertrophy?
Myocardial contrast echocardiography can effectively differentiate between physiological and pathological myocardial hypertrophy using peak intensity (A-value) as a discriminator.
Effect estimate: AUC 0.904
OBJECTIVE: To quantitatively evaluate myocardial perfusion levels in patients with physiological and pathological myocardial hypertrophy using myocardial contrast echocardiography (MCE), and to investigate the diagnostic value of MCE parameters for differentiating between these conditions. METHODS: From June 2023 to December 2024, 25 hypertensive patients with myocardial hypertrophy (pathological hypertrophy group), 25 healthy athletes (physiological hypertrophy group), and 25 healthy controls were enrolled. All participants underwent two-dimensional echocardiography and MCE. Myocardial perfusion parameters-peak intensity (A-value), wash-in slope (β-value), and myocardial blood flow (MBF)-were quantified using a 17-segment model. Differences in perfusion parameters were compared, and receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic efficacy. RESULTS: Compared with controls, the physiological hypertrophy group showed significantly increased peak intensity (A-value) and MBF (p 8.13 dB (AUC = 0.904) for discriminating exercise-induced physiological hypertrophy from hypertension-induced pathological hypertrophy. CONCLUSION: MCE enables quantitative assessment of myocardial perfusion in hypertrophic patients. The A value, reflecting microvascular density, serves as a reliable discriminator between physiological and pathological hypertrophy.
Chunyao et al. (Fri,) conducted a observational in Myocardial hypertrophy (n=75). Myocardial contrast echocardiography (MCE) vs. Healthy controls and between hypertrophy types was evaluated on Discrimination between exercise-induced physiological hypertrophy and hypertension-induced pathological hypertrophy (AUC 0.904). Myocardial contrast echocardiography peak intensity (A-value > 8.13 dB) discriminated exercise-induced physiological from hypertension-induced pathological hypertrophy (AUC 0.904).