Horizontal Heart Orientation as a Mechanistic Contributor to Platypnea–Orthodeoxia Syndrome in Patent Foramen Ovale

Key Points

• The study aims to investigate how altered heart orientation contributes to platypnea-orthodeoxia syndrome in patients with patent foramen ovale.
• Examined cardiac orientation in patients with patent foramen ovale.
• Considered the relationship between heart orientation and hypoxemia.
• Altered heart orientation was linked to the development of platypnea-orthodeoxia syndrome.
• Closure of the patent foramen ovale may result in significant clinical improvement.