What question did this study set out to answer?

This study aims to identify risk factors and predictive markers for Mycoplasma pneumoniae infection in children.

May 3, 20260 citations

Analysis of risk factors of Mycoplasma pneumoniae infection in children.

Key Points

This study aims to identify risk factors and predictive markers for Mycoplasma pneumoniae infection in children.
Analyzed 2042 children with suspected Mycoplasma pneumoniae infection treated for the first time at Civil Aviation General Hospital.
Divided children into pneumonia group (1637 confirmed cases) and non-pneumonia group (405 cases) based on infection status.
Utilized logistic regression, Spearman correlation, and LASSO regression analysis for data evaluation.
Neutrophil percentage was significantly lower in the non-MP infection group compared to the MP infection group (P < .001).
Lymphocyte percentage and hemoglobin levels were lower in the MP infection group with statistically significant differences (P < .05).
The NLR showed diagnostic value with an AUC of 0.624, sensitivity of 0.798, and specificity of 0.558.

Abstract

To explore the risk factors and predictive value of Mycoplasma pneumoniae (MP) infection in children. A total of 2042 children with suspected Mycoplasma pneumoniae infection who were treated for the first time at Civil Aviation General Hospital from October 2023 to December 2023 were selected as the study subjects. Among them, 1637 cases were confirmed as Mycoplasma pneumonia-infected and were included in the pneumonia group, while the remaining 405 cases were non-Mycoplasma pneumonia-infected and were included in the non-Mycoplasma pneumonia group. The clinical data of the 2 groups of children (including gender, age, initial symptoms, laboratory indicators, etc) and the risk factors of MP infection in children were compared, and the receiver operating characteristic curve was analyzed. This study showed that the percentage of neutrophils in the non-MP infection group was significantly lower than that in the MP infection group, and the difference was statistically significant (P < .001). When comparing the percentages of lymphocyte percentage (LY) and hemoglobin in the 2 groups of children, the Mycoplasma pneumonia-infected group was lower than the non-Mycoplasma pneumonia-infected group, and the differences were both statistically significant (P < .05). Logistic regression analysis revealed that white blood cell and neutrophil-to-lymphocyte ratio (NLR) might be valuable markers for predicting MP infection. The Spearman correlation indicated that LY was collinear with the occurrence of MP infection, and Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis demonstrated that both LY and NLR might be valuable markers for predicting MP infection (P < .05). Receiver operating characteristic curve analysis revealed that the area under the curve of the NLR for diagnosing MP infection was 0.624, with a cutoff value of 1.36 (sensitivity of 0.798 and specificity of 0.558). In the diagnosis of MP infection, the consistency between the RNA method and the immunogold colloidal method was poor (Kappa = 0.108, P < .05). The consistency between the RNA method and the immunogold colloidal method in the diagnosis of MP infection is poor. Both the white blood cell and NLR are valuable markers for MP infection.

KI fragen

Bookmark

View Full Paper