PDA@MnOx nanozyme-engineered mesenchymal stem cells for severe acute pancreatitis therapy via modulation of ROS-inflammation-microbiota homeostasis.

Key Points

• The aim is to evaluate the effectiveness of nanozyme-engineered mesenchymal stem cells in treating severe acute pancreatitis (SAP) by restoring homeostasis of reactive oxygen species, inflammation, and microbiota.
• Utilized nanozymes in mesenchymal stem cells for therapeutic application.
• Assessed the modulation of ROS-inflammation-microbiota homeostasis.
• Implemented in vivo tracking of treatment effects.
• Significantly improved SAP outcomes through the modulation of ROS-inflammation-microbiota.
• Achieved restoration of homeostasis in the pathological microenvironment.