Electrochemotherapy (ECT) combined with gene electrotransfer of interleukin-12 (IL-12 GET) has shown promising results in the treatment of canine mast cell tumors (MCTs). However, when tumors are located in anatomically challenging sites, there is a need for the use of a single-needle electrode to access the tumor. Therefore, this case report aimed to evaluate the feasibility and effectiveness of using a bipolar single-needle electrode in a dog with an MCT on the nasal planum. The 2-cm 3 tumor was treated with the simultaneous intratumoral administration of cisplatin (CDDP) and a plasmid encoding canine IL-12, followed by the application of electric pulses using a bipolar single-needle electrode. In addition, the dog was treated with a tyrosine kinase inhibitor. We observed a reduction in microvessel density 6 months after treatment, along with a decreased number of proliferating cells. These combined interventions resulted in long-term local tumor control for 18 months before recurrence occurred. Importantly, our results demonstrated that the bipolar single-needle electrode approach was both feasible and effective. In conclusion, using IL-12 GET with a bipolar single-needle electrode for the treatment of MCTs is a practical and effective therapeutic option, particularly for tumors located in difficult-to-treat anatomical sites.
Tratar et al. (Wed,) studied this question.
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