Dual-function hydrogel microspheres coordinate immune regulation and osteogenesis coupling to promote femoral regeneration Authors

Key Points

• This research aims to explore how hydrogel microspheres can enhance bone regeneration by coordinating immune regulation and osteogenesis.
• Utilized dual-function hydrogel microspheres to target macrophage M2 polarization.
• Assessed the impact on skeletal immune microenvironment and bone defect repair.
• Evaluated the effectiveness of the strategy in a femoral regeneration model.
• Enhanced macrophage M2 polarization correlated with improved bone regeneration outcomes.
• Significant increase in bone healing metrics compared to control groups.
• Demonstrated a synergistic effect on bone repair through immune modulation.