Synthesizing Multisubstituted Cyclohexanes via Palladium‐Catalyzed 4+2 Cycloaddition

Key Points

• The aim is to synthesize cyclohexanes with three contiguous stereocenters through a palladium-catalyzed cycloaddition.
• The reaction combines methylene-δ-valerolactones with trisubstituted olefins using palladium as a catalyst.
• Chiral ligands are employed to generate chiral adducts under mild conditions.
• The reaction produces cyclohexanes with good yields and moderate enantioselectivity.
• Broad substrate scope indicates versatility in the reaction.