Sarcopenia independently increased the risk of ventricular remodelling (OR 2.230) after coronary artery bypass grafting in elderly patients with coronary heart disease.
Observational (n=135)
No
Does sarcopenia predict ventricular remodelling in elderly patients with coronary heart disease following coronary artery bypass grafting?
Sarcopenia is an independent risk factor and strong predictor for ventricular remodelling after CABG in elderly patients with coronary heart disease.
Effect estimate: OR 2.230 (95% CI 1.37-3.62)
Absolute Event Rate: 56.25% vs 19.33%
p-value: p=<0.001
Objective To investigate the association between sarcopenia and ventricular remodelling after coronary artery bypass grafting (CABG) in elderly patients with coronary heart disease (CHD). Methods A total of 135 elderly patients with CHD admitted to hospital between February 2021 and May 2023 were prospectively selected. According to whether ventricular remodelling occurred during the follow-up period, patients were divided into an occurrence group and a non-occurrence group. Results The incidence of ventricular remodelling after CABG in elderly patients with CHD was 23.70% (32/135). Significant differences between the two groups were observed in smoking history, diabetes history, prevalence of sarcopenia, degree of preoperative coronary stenosis, levels of lipoprotein (a) (Lp(a)), uric acid (UA), protease-activated receptor 2 (PAR2), monocyte-to-HDL ratio (MHR), and suspended red blood cell input ( P 0.05). Multivariable logistic regression analysis identified smoking history odds ratio (OR) = 2.186, 95% confidence interval (CI) 1.34–3.57, diabetes history (OR = 2.171, 95% CI 1.32–3.58), sarcopenia (OR = 2.230, 95% CI 1.37–3.62), a high degree of preoperative coronary stenosis (OR = 2.223, 95% CI 1.36–3.64), elevated Lp(a) (OR = 2.143, 95% CI 1.32–3.49), elevated UA (OR = 2.164, 95% CI 1.31–3.58), elevated PAR2 (OR = 2.192, 95% CI 1.32–3.64), and elevated MHR (OR = 2.201, 95% CI 1.32–3.68) as independent risk factors for ventricular remodelling after CABG in the study population. Analysis showed that sarcopenia predicted ventricular remodelling with a sensitivity of 90.0%, specificity of 47.0%, and an area under the curve of 0.772 (95% CI 0.68–0.86, P 0.0001). Conclusion Sarcopenia is a risk factor affecting ventricular remodelling after CABG in elderly patients and shows strong predictive efficacy in this population.
Li et al. (Wed,) conducted a observational in Coronary heart disease (n=135). Sarcopenia vs. No sarcopenia was evaluated on Ventricular remodelling (ΔLVEDV ≥ 15%) (OR 2.230, 95% CI 1.37-3.62, p=<0.001). Sarcopenia independently increased the risk of ventricular remodelling (OR 2.230) after coronary artery bypass grafting in elderly patients with coronary heart disease.