Design, synthesis, and biological evaluation of novel SN38-sulfonamide conjugates as Topo I/CA IX dual inhibitors inducing ferroptosis in colorectal cancer

Key Points

• This research aims to develop SN38-sulfonamide conjugates that act as dual inhibitors for colorectal cancer therapy.
• Designed and synthesized SN38-sulfonamide conjugates
• Conducted biological evaluation of the inhibitors
• Performed structure-activity relationship analysis
• Novel dual inhibitors target Topo I and CA IX
• Conjugates induce ferroptosis in colorectal cancer models
• Demonstrated potential therapeutic effects against cancer