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Protocol for mapping murine myeloid bone marrow progenitors and their differentiation into CD103+ cDC1s and CD301b+ cDC2s. | Synapse
May 6, 2026
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Protocol for mapping murine myeloid bone marrow progenitors and their differentiation into CD103+ cDC1s and CD301b+ cDC2s.
DV
Damir Vurnek
Jena University Hospital
GT
Giorgi Tchitashvili
Friedrich-Alexander-Universität Erlangen-Nürnberg
AS
Anna Seichter
Friedrich-Alexander-Universität Erlangen-Nürnberg
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Key Points
To outline a protocol for mapping murine myeloid bone marrow progenitors and their differentiation.
Use a specific mapping protocol to identify bone marrow progenitors
Analyze differentiation pathways leading to CD103+ cDC1s and CD301b+ cDC2s
Employ murine models for accurate results
Identified key steps in the differentiation of myeloid progenitors
Mapped the transition of progenitors to mature dendritic cell subsets
Provided foundational insights into immune system development
Abstract
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Vurnek et al. (Sat,) studied this question.
synapsesocial.com/papers/69fa8ef304f884e66b5316d0
https://doi.org/https://doi.org/10.1016/j.xpro.2026.104508
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