Pd-Catalyzed Site-Selective Dehydrogenative Alkenyl Etherification of Tyrosine Residues in Peptides and Proteins

Key Points

• The aim is to develop a selective method for the alkenyl etherification of tyrosine residues in proteins.
• Palladium-catalyzed reaction
• Cross-coupling alkenyl etherification
• Synthesis of tyrosine-derived alkenyl ethers
• Moderate to good yields of alkenyl ethers
• Site-selective modification of tyrosine residues
• Facilitated synthesis of diverse compounds