What question did this study set out to answer?

To develop a comprehensive gas chromatographic method for identifying residual solvents.

May 6, 2026

Advanced GC Method for Comprehensive Residual Solvent Analysis: Overcoming Co-elution with Orthogonal Columns and Quantification by Mass Spectrometry

RARuba A ArulrajBristol-Myers Squibb (India)VVVinay VishwanathBristol-Myers Squibb (India)SDSharad DucheBristol-Myers Squibb (India)

Key Points

To develop a comprehensive gas chromatographic method for identifying residual solvents.
Developed a gas chromatographic method
Targeted 57 residual solvents listed in ICH guidelines
Achieved analysis in a single 30-minute chromatogram
Identified and quantified residual solvents efficiently
Overcame challenges of co-elution with orthogonal columns

Abstract

A robust and comprehensive gas chromatographic method was developed to identify and quantify the 57 residual solvents listed in the ICH guidelines, all in a single, 30-minute chromatogram. The proposed...

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