respectively. Moreover, the accumulation trends varied across tissues depending on the exposure concentration. Chlorpyrifos and endosulfan would not be concerning for human health in aquaculture environments after 21 days of depuration, as their %ADI values were 0.45 and 0.17, when concentrations remained under 2 μg·L⁻¹. DDT exhibited particularly high accumulation and persistence, with the residue level and dietary intake risk exceeding limits, demonstrating an unacceptable food safety risk. Based on the anatomical structure of sea cucumbers and the principle of passive diffusion, we optimized the existing kinetic models and developed a multicompartmental toxicokinetic model applicable to organic insecticides in sea cucumbers. This model could be used to predict tissue-specific organic insecticide concentrations under natural environmental conditions. Our findings also provide a basis for ecological and human dietary risk assessment of organic insecticides in sea cucumber aquaculture, thereby promoting the sea cucumber industry's healthy and sustainable development.
Cong et al. (Wed,) studied this question.