What question did this study set out to answer?

To develop a mild and efficient methodology for synthesizing fluorinated 1,2-naphthoquinones.

May 6, 2026Chemical Communications0 citations

Synthesis of Fluorinated 1,2-Naphthoquinones from o-Trifluoromethylbenzylamines via Defluorinative Approach

RKRushikesh R. Kusmude MYMahipal Yadav SKSiddhant A. Kale

Key Points

To develop a mild and efficient methodology for synthesizing fluorinated 1,2-naphthoquinones.
Utilized o-trifluoromethylbenzylamine derivatives and enolizable esters in the synthesis process.
Implemented a defluorinative approach for the transformation.
Evaluated the efficiency and conditions of the methodology.
Successfully synthesized various fluorinated 1,2-naphthoquinones.
Demonstrated high efficiency in the defluorinative approach.

Abstract

A highly efficient and mild defluorinative methodology has been developed to synthesize various fluorinated 1,2-naphthoquinones from readily accessible o-trifluoromethylbenzylamine derivatives and enolizable esters. The resultant fluorinated 1,2-naphthoquinones are subsequently transformed...

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Cite This Study

Kusmude et al. (Thu,) studied this question.

synapsesocial.com/papers/69fa989404f884e66b5325c3 https://doi.org/https://doi.org/10.1039/d6cc01497f

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