Background. Currently, a positive effect of a collagen hydrolysate, manufactured by «PERVIY ZHIVOY COLLAGEN» OOO, on the morphofunctional state of the skin from the oral administration has been proven. At the same time, studies in the field of changes in the microbiological diversity of the skin in presence of the drug administration are little covered. Objective. To assess the impact of hydrolyzed collagen-based drugs on the morphofunctional state of the skin and its appendages, as well as to study changes in the biodiversity of skin microbiota, nails and hair before and after application of this drug. Material and methods. The study included 15 women aged 45—55 in menopause, who had not previously taken the collagen hydrolysate drugs and replacement therapy. During the observation period, 2 visits were carried out: before and after the drug administration with an interval of 3 months. Each visit included a dermatologist’s examination, skin Doppler ultrasonography, survey for assessment of the nail plate condition and microbiological study of the facial skin in the area around the crow’s feet, hair and nail plates. Identification of microorganisms was done using the MALDI-ToF mass spectrometry method. Results. Positive dynamics in the morphofunctional state of the skin, namely statistically significant increase in the dermis thickness and skin hydration level, was revealed. Statistically significant decrease in the frequency of occurrence of B. cereus in the skin, nail and hair microbiota, S. warneri in the composition of the nail microbiota, as well as statistically significant increase in the frequency of S. pasteuri identification in the hair microbiota and S. epidermidis — in the nail plates were detected. Conclusion. The use of hydrolyzed collagen-based dietary supplements in dermatology and cosmetology remains relevant. The administration of hydrolyzed collagen-based drugs contributes to increase in skin hydration, increase in thickness of the dermal layer and normalization of the skin microbiota.
Arseneva et al. (Thu,) studied this question.