What question did this study set out to answer?

To study the responses of olanzapine as a 5-HT4 receptor antagonist in melanophores of Rasbora daniconius.

May 6, 2026BIOINFOLET - A Quarterly Journal of Life Sciences0 citations

Responses of Olanzapine as an Antagonist to 5-Hydroxytryptamine on Isolated Scale of Melanophores of Rasbora daniconius (Ham.)

DSDr. Sudhir Kumar Srivastava UGUmesh Gaur

Key Points

To study the responses of olanzapine as a 5-HT4 receptor antagonist in melanophores of Rasbora daniconius.
Conducted experiments on isolated melanophores from Rasbora daniconius.
Measured the melanophore size index as a key parameter.
Investigated the effects of olanzapine on 5-Hydroxytryptamine responses.
Olanzapine significantly inhibited the aggregator effect of 5-HT on melanophores.
Evidence supports the presence of 5-HT4 receptors in Rasbora daniconius melanophores.

Abstract

AbstractResponses of Olanzapine, a specific 5-HT4 receptor antagonist,were studied in dorso-lateral region as well as in band region melanophores of Rasbora daniconius. The melanophore size index (MSI) was considered as a parameter for studying responses. Olanzapine (1.6 x 10-5M), the specific 5-HT4 receptor antagonist, strongly inhibited the aggregator effect of 5-HT, which provided a strong evidence for the presence of 5-HT4 receptor in Rasbora daniconius melanophores.

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