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A new 4-atom linker enables PROTAC development and imaging | Synapse

May 6, 2026RSC Chemical Biology0 citationsOpen Access

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A new 4-atom linker enables PROTAC development and imaging

SLSpyros Letsios GCGiovana Carrasco MLMartin Lee

Key Points

This research aims to explore the impact of a new 4-atom linker on PROTAC development and its imaging capabilities.
Development of a novel 4-atom linker for PROTACs
Assessment of linker effects on biological activity
Imaging techniques employed to visualize PROTACs
The 4-atom linker showed improved biological activity compared to previous linkers
Effective imaging of PROTACs was achieved using the novel linker

Abstract

Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules, emerging as a promising class of drugs.Amongst their structural components, the linker moiety plays a pivotal role in modulating their biological activity and...

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Cite This Study

Letsios et al. (Wed,) studied this question.

synapsesocial.com/papers/69faa22704f884e66b532c43 https://doi.org/https://doi.org/10.1039/d6cb00127k