What question did this study set out to answer?

Investigate a new method for hazard identification of antisense oligonucleotides using whole-embryo culture.

May 6, 2026Nucleic Acid Therapeutics0 citations

Rat and Rabbit Whole-Embryo Culture as a New Approach Method for Unlabeled Therapeutic Antisense Oligonucleotide Hazard Identification with No Requirement for Microinjection or Assisted Transfection

SBSara M Bender SCS Chapman SNSreenivas Nannapaneni

Key Points

Investigate a new method for hazard identification of antisense oligonucleotides using whole-embryo culture.
Developed whole-embryo culture techniques in rats and rabbits.
Evaluated the safety and efficacy of unlabeled therapeutic antisense oligonucleotides.
Reduced reliance on microinjection and animal use.
Enabled robust developmental hazard identification for antisense oligonucleotides.
Informed future safety assessment strategies for regulatory purposes.

Abstract

studies, reducing animal use and required test material amounts, while enabling robust developmental hazard identification for ONTs. This work informs future safety assessment strategies and regulatory guidance for ONTs.

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Bender et al. (Mon,) studied this question.

synapsesocial.com/papers/69faa25e04f884e66b532f65 https://doi.org/https://doi.org/10.1177/21593337261442471

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