Inorganic arsenic and its methylated metabolites induce pulmonary immunosuppression via the p62-Keap1-Nrf2 positive feedback loop-mediated M2 macrophage polarization.

Key Points

• This research investigates how inorganic arsenic and its metabolites affect immune responses in the lungs.
• Examined the effects of inorganic arsenic on immune cells in the lungs
• Focused on the role of M2 macrophage polarization
• Investigated the p62-Keap1-Nrf2 signaling pathway
• Inorganic arsenic was found to induce M2 macrophage polarization
• This effect contributes to pulmonary immunosuppression
• The mechanism involves a positive feedback loop with p62-Keap1-Nrf2 signaling