Bone marrow hemodilution assessment in multiple myeloma MRD by next generation flow cytometry - a mini review

Key Points

• The review explores the impact of bone marrow hemodilution on MRD evaluation in multiple myeloma.
• Review definitions and markers related to hemodilution and MRD.
• Summarize mitigation strategies and challenges in standardization.
• Discuss the role of next generation flow cytometry in assessing MRD.
• Bone marrow hemodilution can lead to false negative results in MRD evaluation.
• Current definitions and indices may not adequately address challenges posed by hemodilution.
• Mitigation strategies are essential for improving standardization in MRD assessments.