= 187). We found a robust and large effect on peak velocity (standardised mean change (SMCC)) = -1.064, 95% CI (confidence intervals) -1.287, -0.84), a less consistent, medium sized effect on latency (SMCC = 0.706, 95% CI 0.285, 1.127), and a medium sized, but non-significant, effect on gain (SMCC = -0.581, 95% CI -1.226, 0.064). These findings confirm the sensitivity of saccadic eye movements to modulation of gamma-aminobutyric acid (GABA) through benzodiazepines and point to the peak velocity in particular as a biomarker for sedative effects in pharmacological research in healthy adults.
Schmidt et al. (Mon,) studied this question.