Plasma Aβ42/Aβ40 and p-tau217/np-tau217 positivity were associated with mild behavioral impairment among older adults with major depressive disorder, but not among those without.
Cross-Sectional (n=330)
Are plasma biomarkers of Alzheimer's disease associated with mild behavioral impairment in older adults with major depressive disorder?
Plasma biomarkers of Alzheimer's disease are associated with mild behavioral impairment specifically in older adults with major depressive disorder.
INTRODUCTION: Plasma biomarkers and mild behavioral impairment (MBI) are associated with dementia risk, but their relationships with major depressive disorder (MDD) are understudied. This study aimed to examine associations between plasma biomarkers of Alzheimer's disease (AD) and MBI among older adults with and without MDD. METHODS: = 330) in the DRIVES Project. Variables included Clinical Dementia Rating (CDR) scale, Mild Behavioral Impariment Checklist (MBI-C), Neuropsychiatric Inventory Questionnaire, Area Deprivation Index, and plasma biomarkers (amyloid beta Aβ 42/Aβ40, phosphorylated tau (p-tau) 181/non-p-tau181, p-tau217/non-p-tau217). Logistic regression assessed associations among MDD, plasma amyloid positivity, antidepressant use, and MBI. RESULTS: Older adults with MDD were more likely to endorse MBI. After adjustment, Aβ42/Aβ40 and p-tau217/np-tau217 positivity were associated with MBI among those with MDD but not among those without. DISCUSSION: Neuropsychatric symptoms (NPS) and biomarkers are AD risk factors. Early identification of MDD may reduce NPS severity, and tracking NPS onset, duration, and frequency is crucial for AD management.
Zhu et al. (Wed,) conducted a cross-sectional in Major depressive disorder (n=330). Plasma biomarkers of Alzheimer's disease vs. Older adults without major depressive disorder was evaluated on Mild behavioral impairment (MBI). Plasma Aβ42/Aβ40 and p-tau217/np-tau217 positivity were associated with mild behavioral impairment among older adults with major depressive disorder, but not among those without.