Introduction: Africa faces a complex and evolving health landscape marked by endemic diseases, emerging infectious threats, fragile health systems, climate change, and geopolitical pressures. In this context, health diplomacy has become an important mechanism for fostering collaboration, mobilizing resources, and advancing collective health security. Objective: This review examines the prospects and obstacles of health diplomacy in Africa and proposes strategic directions to enhance its effectiveness in achieving equitable and sustainable health outcomes. Methods: A narrative review was conducted using a purposive search of literature published between 2016 and 2026 across PubMed, Scopus, and Google Scholar, complemented by policy documents and institutional reports. A total of 152 records were identified, with 43 sources included after screening. Data were analyzed through thematic synthesis, guided by decolonial theory and liberal institutionalism to interpret governance dynamics. Results: Key prospects include strengthened regional collaboration through African Union mechanisms, improved bargaining power in global health governance, increased engagement of non-state actors, and the integration of digital health innovations. However, significant obstacles persist, including political diversity, sovereignty concerns, resource inequalities, weak institutional capacity, coordination gaps, and external influence. Historical power asymmetries continue to shape negotiation processes and health governance structures. Conclusion: Health diplomacy offers a critical pathway to address shared health challenges in Africa. Strengthening its impact requires investment in diplomatic capacity, policy alignment, digital innovation, and equitable partnerships, supported by a unified and equity-driven continental approach.
Majani Edward (Fri,) studied this question.