Synthesis of spiro-lactam hydrazones by clay catalysis: toxicity, antioxidant, hypolipidemic and In silico assessments

Key Points

• The research aims to synthesize spiro-lactam hydrazones and evaluate their biological activities.
• Synthesis of spiro-lactam hydrazones using Moroccan Es-sifa natural clay as a catalyst.
• Structural characterization of the synthesized compounds.
• In silico studies to assess the interactions and properties of compounds.
• Evaluation of toxicity and antioxidant activities of the synthesized hydrazones.
• Demonstrated significant antioxidant properties of the synthesized spiro-lactam hydrazones.
• Identified potential hypolipidemic effects through biological activity assessments.