Why in vivo models of disease remain indispensable

Key Points

• The aim is to emphasize the essential role of in vivo models in the study of diseases.
• Discussion of the challenges faced by alternative models to animal research.
• Emphasis on the importance of validation against complex animal models.
• Call for ongoing community support for animal modeling.
• Integration with model organisms is crucial for effective disease research.
• Validation against animal models strengthens the legitimacy of alternative approaches.