A Biomimetic Nanozyme Engineered via Coordination and Confinement for Photothermal-Reinforced Catalytic Detection of Extracellular Vesicles and Diagnosis of Cancer

Key Points

• The study aims to develop a biomimetic nanozyme for the photothermal detection of extracellular vesicles related to cancer.
• Engineered nanozyme created through coordination and confinement techniques.
• Multiple aptamer-MB probes target cancer markers (HER2, MUC1, GPC3).
• A sensor array was constructed, integrating machine learning for classification.
• Analysis distinguishes liver cancer patients from those with hepatitis and healthy individuals.
• The assay shows potential for noninvasive cancer diagnosis.
• High accuracy in classifying different cancer types using sensor arrays.