What question did this study set out to answer?

To propose a revised nomenclature for CHILD syndrome and report on an effective treatment in a young child.

May 7, 2026Clinical and Experimental Dermatology0 citations

CHILD Syndrome without Limb Defects in a 1-year-old: revised nomenclature and successful treatment with Topical 2% Simvastatin/2% Cholesterol

JWJoseph Wyer CMCelia Moss PPPratima Poudel

Key Points

To propose a revised nomenclature for CHILD syndrome and report on an effective treatment in a young child.
Case report of a 1-year-old with CHILD syndrome without limb defects
Treatment administered using topical 2% simvastatin combined with 2% cholesterol
Nomenclature revision aligned with ichthyoses classification
Successful treatment outcome noted in the patient
Improvements observed following pathogenesis-based therapy
Revised nomenclature proposed for clarity in classification

Abstract

The recent publication of a new gene-based classification for the ichthyoses has drawn attention to naming anomalies in other conditions. An example is CHILD syndrome (Congenital Ichthyosiform Erythroderma with Limb Defects) without Limb Defects, as reported here. We suggest nomenclature in line with the system used for the ichthyoses. We also report successful pathogenesis-based treatment in a very young child.

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