Redox-responsive Fe(II)/Fe(III) MRI probes with pentadentate or hexadentate macrocyclic ligands

Key Points

• The aim is to explore Fe(II) complexes as agents for monitoring inflammation-related peroxide production.
• Studied Fe(II) complexes of TACN with pendant groups.
• Assessed the effectiveness of pentadentate vs hexadentate ligands.
• One ligand demonstrated redox-responsiveness for effective monitoring.
• Inflammation was indicated by changes in peroxide levels through the MRI probes.