Abstract Chronic metabolic diseases such as type 2 diabetes (T2D) and obesity remain major global health challenges, driven by impaired energy regulation, insulin resistance, and systemic inflammation. Traditional treatment paradigms emphasize symptom control, whereas emerging strategies target the root cause of metabolic dysfunction. Mobile health (mHealth) applications provide scalable platforms to support lifestyle change, behavior modification, and personalized care. Next-generation tools, including digital twin (DT)–enabled technologies, integrate real-time physiological and behavioral data to deliver individualized guidance. To synthesize current evidence and multidisciplinary expert perspectives on the efficacy, safety, usability, regulatory frameworks, and ethical considerations of mHealth applications in T2D remission and sustained weight loss. This position statement was developed through structured expert engagement at DTechCon 2025, the 4 th World Congress of Diabetes Technology and Therapeutics, held in Jaipur. Drawing on the literature from systematic reviews, randomized controlled trials, and implementation studies, thematic expert discussions were conducted across six key domains. The resulting recommendations reflect shared clinical, technological, and ethical insights, though no formal Delphi process was undertaken. The expert panel collaboratively developed a set of consensus-informed recommendations addressing six domains: efficacy, safety, usability, regulatory challenges, ethical principles, and implementation feasibility. While not quantitatively scored, the guidance reflects broad agreement among contributors from endocrinology, digital health, clinical pharmacology, behavioral science, and policy. This position statement offers evidence-informed, practice-oriented guidance on the responsible integration of mHealth interventions into metabolic care. Inclusive design, strong data protection, clinical validation, and integration into care workflows are emphasized. Ongoing stakeholder engagement, particularly with patients and primary care providers – will be essential to enhance real-world applicability and equity.
Samajdar et al. (Tue,) studied this question.