Radical Bromination/Cascade Cyclization: A Facile Approach to Benzimidazole-Fused Isoquinolinones

Key Points

• To develop a radical bromination/cyclization strategy for synthesizing specific brominated compounds.
• Developed a radical bromination and cyclization approach.
• Utilized tetrabutylammonium bromide as a bromide source.
• Synthesis focused on benzimidazo[2,1-a]isoquinolin-6(5H)-ones.
• Demonstrated efficiency in synthesizing the target compounds.
• Provided a safe and cost-effective bromide source.