Zinc is an essential trace element critical for animal growth, immune function, and antioxidant defense.Organic zinc sources chelated with amino acids are increasingly used as alternatives to inorganic zinc due to their potentially higher bioavailability.This study compared intracellular accumulation and transcellular transport of inorganic zinc sulfate (ZnS) and three organic zinc sources: zinc hydroxymethionine (ZnM), zinc valine (ZnV) and zinc glycine (ZnG) in the porcine intestinal epithelial IPEC-J2 cell model, with particular emphasis on the effects of high calcium levels.Results showed that ZnM and ZnG exhibited significantly greater intracellular zinc accumulation at 50-100 M and higher transcellular transport efficiency than ZnS (P < 0.05), with ZnG displaying the highest transport rate (P < 0.05).High calcium (2400 M) promoted apical zinc uptake and intracellular retention across
Gong et al. (Thu,) studied this question.