What question did this study set out to answer?

The aim is to identify trauma-related and patient-level risk factors associated with multiregional spinal column injury in children.

May 7, 2026

Risk Factors for Multiregional Spinal Column Injury

Key Points

The aim is to identify trauma-related and patient-level risk factors associated with multiregional spinal column injury in children.
Prospective analysis of patients <18 years from 72 trauma centers in the US.
Inclusion of children undergoing cervical spine evaluation after blunt multisystem trauma.
Multivariate analysis of trauma-related factors including mechanism of injury, rib fractures, hemothorax, bowel injury, pelvic fracture, and clinically significant cervical spine injury.
7.5% of patients experienced thoracolumbar injury (TLI).
0.81% had cervical spine injury (CSI) requiring treatment.
19% of patients with clinically significant CSI also had TLI, with multiple trauma factors identified as significant risk indicators.

Abstract

Study Design. Subanalysis of a prospective, multicenter, observational study at 72 US adult, pediatric, and mixed trauma centers. Objective. We investigated trauma-related risk factors and patient-level factors associated with multiregional spinal column injury, defined as cervical spine injury (CSI) requiring treatment and thoracolumbar injury (TLI). Summary of Background Data. Traumatic spinal injury causes morbidity and mortality in pediatric patients. Injuries to multiple spinal column regions require early identification and thoughtful management. Methods. All children <18 years undergoing cervical spine evaluation after blunt multisystem trauma were prospectively identified and enrolled. Clinically significant CSI was defined by cervical spine surgery or halo placement. TLI incidence and management was recorded. The primary outcome was multiregional spinal column injury (CSI+TLI). Results. Of 19,651 enrolled patients, 1484 children (7.5%) experienced a TLI, 159 (0.81%) had CSI requiring treatment, and 30 (0.15%) had CSI+TLI. Multivariate analysis revealed that the trauma-related factors mechanism of injury ( P <0.001), rib fractures (odds ratio (OR) 2.8 2.3-3.4), hemothorax/pneumothorax (OR 2.0 1.7-2.4), bowel injury (OR 4.0 2.9-5.4), pelvic fracture (OR 1.5 1.2-1.9), and clinically significant CSI (OR 1.9 1.2-2.9) were independently associated with TLI. Of the 159 children with clinically significant CSI, 30 also experienced TLI (19%). Multivariate analysis identified prehospitalization intubation (OR 3.1 1.1-8.4) and rib fractures (OR 3.9 1.2-12.8) as independent associations with CSI+TLI. Conclusions. Of children with CSI requiring treatment, 19% experienced TLI. MOI and various trauma-related injuries were independently associated with TLI, whereas prehospitalization intubation and rib fractures were independent risk factors for CSI+TLI. These factors should trigger screening for multiregional spinal column injury in pediatric trauma patients. Furthermore, if there is known TLI, the cervical spine should be evaluated, and if there is significant CSI, then dedicated imaging of the thoracic and lumbar spine is indicated. Level of Evidence. III

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Risk Factors for Multiregional Spinal Column Injury

Key Points

Abstract

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