An integrative proteomic approach to reveal altered signaling modules during Alzheimer’s disease progression in PS19 tauopathy mice

Key Points

• The aim is to identify altered signaling modules involved in the progression of Alzheimer’s disease in PS19 tauopathy mice.
• Integrated proteomic analysis in PS19 tauopathy mice
• Assessment of various signaling pathways
• Use of biomarkers such as dopamine and serotonin levels
• Altered dopamine and serotonin signaling pathways identified in PS19 mice
• Increased levels of specific biomarkers linked to disease progression
• Significant differences in signaling module activity compared to control groups

Abstract