Network-level structural alterations distinguish persistent from remitted post-traumatic stress disorder: a morphometric covariance approach

Key Points

• This research aims to identify structural brain differences that distinguish persistent PTSD from remitted cases.
• Utilized morphometric covariance approach to analyze brain imaging data.
• Focused on gray matter volume reductions and connectivity patterns between cognitive control and limbic-interoceptive networks.
• Identified progressive gray matter volume reductions in persistent PTSD compared to remitted cases.
• Found compensatory hyperconnectivity between cognitive control and limbic regions, linked to symptom regulation.

Abstract