OBJECTIVE: This study aimed to investigate the correlations of serum uric acid (SUA) and glycated hemoglobin (HbA1c) levels with mild cognitive impairment (MCI) in patients with comorbid type 2 diabetes mellitus (T2DM) and hypertension, and to further identify potential risk factors associated with MCI. METHODS: = 52) based on Mini-Mental State Examination (MMSE) scores. The correlations of SUA and HbA1c with MMSE scores, their predictive value for MCI, their relationships with clinical variables, and independent risk factors for MCI were evaluated using Spearman correlation, receiver operating characteristic curve, and logistic regression analyses. RESULTS: = -0.419 and -0.510). For predicting MCI, the area under the ROC curve (AUC) was 0.742 for SUA (sensitivity: 78.85%, specificity: 62.16%, cut-off value: 319.31), 0.781 for HbA1c (sensitivity: 48.08%, specificity: 94.59%, cut-off value: 8.94), and 0.851 for their combination (sensitivity: 73.08%, specificity: 85.14%, cut-off value: 0.42). Elevated SUA and HbA1c levels and older age were independent risk factors for MCI, whereas higher IBIL and HDL-C levels and reading habits were protective factors. CONCLUSIONS: SUA and HbA1c levels were elevated in older patients with T2DM and hypertension who developed MCI. These markers were identified as independent risk factors for MCI in patients with T2DM-hypertension, aiding in the prediction of MCI occurrence in these patients.
Mei Li (Wed,) studied this question.