This study examines the coordination chemistry of ceftiofur by creating and carefully characterizing its metal complexes with Fe(III), Co(II), Ni(II), Cu(II), Cd(II), and Hg(II). The interaction between the ligand and selected metal ions resulted in the development of stable complexes, primarily exhibiting a 1:1 metal-to-ligand ratio, whereas the Cd(II) derivative suggested a 1:2 stoichiometric configuration. Ceftiofur coordinates through several donor centers, such as carbonyl oxygen, amino nitrogen, and carboxylate oxygen atoms, according to infrared and electronic spectral studies. Electronic transition assignments and magnetic susceptibility data, which mostly suggested octahedral coordination geometries. Metal oxide residues were eventually produced by successive degradation patterns shown by thermal analysis. The surface morphology and crystalline nature of the complexes were examined using scanning electron microscope and X-ray diffraction techniques. Additionally, compared to the uncoordinated ligand, the coordinated systems demonstrated different antibacterial and antioxidant qualities. Favorable binding affinities were found in molecular docking simulations against the 4R6E breast cancer receptor, highlighting the function of metal coordination in regulating the biological potential of ceftiofur-based drugs.
Elasala et al. (Wed,) studied this question.