In 100 patients undergoing TAVI, iron deficiency defined by TSAT < 20% was associated with no significant post-procedure changes in left ventricular myocardial work indices at 1-year follow-up.
Observational (n=100)
Does iron deficiency impact changes in left ventricular myocardial work indices after TAVI in patients with severe aortic stenosis?
In patients undergoing TAVI for severe aortic stenosis, iron deficiency defined by TSAT < 20% is associated with an absence of significant post-TAVI changes in left ventricular myocardial work indices.
BACKGROUND: Aortic stenosis (AS) increases left ventricular (LV) afterload and systolic pressure (LVSP). Left ventricular myocardial work (LVMW) enables early detection of LV dysfunction. Recent evidence suggests that ID may reduce LVMW parameters, raising the question of whether ID further impairs LV systolic performance in patients with AS undergoing transcatheter aortic valve implantation (TAVI). METHODS: We evaluated 100 patients with severe AS scheduled for TAVI between March 2021 and November 2022. All underwent ID screening according to the classic and novel ID definitions and echocardiographic assessment of LVMW before TAVI and at the 1-year follow-up. RESULTS: Elimination of AS was observed within the 1-year follow-up in the whole population. Despite stable ejection fraction (EF) and global longitudinal strain (GLS), LVMW indices such as global work index (GWI) and global constructive work (GCW) significantly decreased from baseline in the entire population. However, when comparing ID and non-ID patients after the procedure, a statistically significant decrease in GWI and GCW was noted at the 1-year follow-up only in the TSAT > 20% group, not in the TSAT < 20% group. We also noted a significant correlation between TSAT status and echocardiographic as well as LVMW indices. When the classic ID definition was used, all LVMW parameters changed similarly in both groups during follow-up. CONCLUSIONS: TAVI significantly influenced the majority of LVMW indices in the overall study population. Using the standard ID definition, ID had no impact on differences in LVMW indices. However, when defined by TSAT < 20%, patients with ID showed no significant post-TAVI changes in LVMW indices.
Błaszkiewicz et al. (Thu,) conducted a observational in Severe aortic stenosis (n=100). Transcatheter aortic valve implantation (TAVI) vs. Iron deficiency (TSAT < 20%) vs non-iron deficiency (TSAT > 20%) was evaluated on Left ventricular myocardial work (LVMW) indices (GWI and GCW). In 100 patients undergoing TAVI, iron deficiency defined by TSAT < 20% was associated with no significant post-procedure changes in left ventricular myocardial work indices at 1-year follow-up.