PRV-delgE/gI/TK immunization preserves blood–brain barrier integrity and limits CNS injury following intracerebral PRV challenge

Key Points

• This study investigates how attenuated PRV immunization can protect against CNS injury caused by PRV infection.
• Administered PRV-delgE/gI/TK immunization pre-challenge.
• Evaluated blood-brain barrier integrity post-intracerebral PRV challenge.
• Assessed CNS injury outcomes following infection.
• Enhanced preservation of blood-brain barrier compared to control (p<0.05).
• Significantly reduced CNS injury markers post-immunization (p<0.01).
• Demonstrated efficacy of immunization strategy in neurotropic PRV infection.