Abstract Number: Esoc2026ot171 Impact of Glucose and Lipid Metabolism on Stroke Severity and Functional Outcome: An Ongoing Prospective Study

Abstract Background and aims Metabolic disturbances, including hyperglycaemia and dyslipidaemia, are frequently observed in patients with acute ischaemic stroke (AIS) and may exacerbate cerebral injury. Although hyperglycaemia and dyslipidaemia have been individually associated with stroke outcomes, their combined prognostic impact remains incompletely characterised. Methods The aim of this study is to investigate glucose and lipid metabolism parameters in patients with acute ischaemic stroke, to determine the association between their alterations and stroke outcome, and to evaluate their influence on stroke severity and recovery dynamics. Results This is an ongoing prospective observational study. A total of 100 patients with confirmed AIS are planned for inclusion; 10 patients have been enrolled so far. Participants are stratified into three groups according to metabolic status: (1) diabetes-related hyperglycaemia, (2) stress hyperglycaemia without diabetes, and (3) normal glucose and lipid levels. All patients undergo neurological examination. Stroke severity is assessed using the National Institutes of Health Stroke Scale (NIHSS), and functional outcome is evaluated with the Barthel Index. Laboratory tests include fasting plasma glucose, glycated haemoglobin (HbA1c), total cholesterol, low-density lipoprotein, high-density lipoprotein, and triglycerides. Neuroimaging consists of brain magnetic resonance imaging or computed tomography and duplex ultrasonography of the brachiocephalic arteries. Conclusions Primary outcome: association between metabolic parameters and stroke severity (NIHSS) will be examined. Secondary outcomes: functional recovery (Barthel Index) and imaging findings will be evaluated. Conflict of interest