What does this research mean for the field?

Polyacrylamide hydrogel-immobilized E. coli cell lysate concurrently adsorbs and enzymatically degrades extracellular antibiotic resistance genes (eARGs) in water, effectively suppressing horizontal gene transfer. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

May 8, 2026Open Access

Polyacrylamide hydrogel-immobilized Escherichia coli cell lysate for efficient removal and reduction in transformability of extracellular antibiotic resistance genes in water

Key Points

This research aims to evaluate the effectiveness of polyacrylamide hydrogel-immobilized Escherichia coli cell lysate in removing extracellular antibiotic resistance genes from water.
Used polyacrylamide hydrogel to immobilize Escherichia coli cell lysate.
Tested the adsorption and enzymatic degradation of extracellular antibiotic resistance genes (eARGs).
Assessed the suppression of horizontal gene transfer via transformation.
Demonstrated concurrent adsorption and enzymatic degradation of eARGs.
Effectively suppressed the horizontal gene transfer, indicating reduced transformability.
Proposed a cost-effective and scalable approach for environmental water treatment systems.

Abstract

cell lysate can concurrently adsorb and enzymatically degrade eARGs, effectively suppressing horizontal gene transfer via transformation. These findings highlight a novel, cost-effective, and scalable biocatalytic strategy for controlling the dissemination of eARGs in water treatment and environmental systems.

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Cite This Study

Li et al. (Wed,) studied this question.

synapsesocial.com/papers/69fd7f3abfa21ec5bbf079d6 https://doi.org/https://doi.org/10.1128/aem.00253-26

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